Human Cells

Pigs grown from fetuses into which human beings stem cells were injected surrender surprised scientists by having cells in which the DNA from the two species is mixed at the or so intimate level.

It is the first time such fused cells have been seen in living creatures. The discovery could have secure implications for xenotransplant - the use of animal tissue and organs in human being - and even the origin of diseases such as HIV.

The adult slovenly persons that had standard human stem cells as fetuses were rig to have pig cells, human cells and the interbreeding cells in their blood and organs.

What we found was completely in all unexpected. We found that the human and pig cells had totally fused in the animals bodies, said Jeffrey Platt, director of the Mayo Clinic Transplantation Biology Program.

Nuclear mix

The hybrid cells had some(prenominal) human and pig surface markers. But, most surprisingly, the hybrid cell nuclei were found to have chromosomal DNA that contained both human and pig genes. The researchers found that about 60 per penny of the animals non-pig cells were hybrids, with the remainder being in effect(p)y human.

Importantly, the team also found that porcine endogenous retrovirus (PERV), which is present in almost all pigs, was also present in the hybrid cells. Previous laboratory work has shown that while PERVs in pig cells cannot infect human cells, those in hybrid cells can. The discovery therefore suggests a serious potential problem for xenotransplantation.

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